東京ビジネスクリニック

FastPASS
Reserve
Telemedicine
Antibody_Test

Five Major Infectious Viruses

These antibody tests for infectious diseases are required for purposes such as overseas travel visas, studying abroad, and hospital or facility training.

  • Types of Antibody Tests
  • Rubella
  • Measles
  • Varicella/Herpes Zoster
  • Mumps
  • Hepatitis B
  • Set Prices

4 Antibody Test Set
(Recommended for individuals or families planning pregnancy)

  • Measles (IgG EIA method)

  • Rubella (IgG EIA / HI method)

  • Mumps (IgG EIA method)

  • Varicella (IgG EIA method)

¥13,500
（¥14,850 tax included）

5 Antibody Test Set
(Basic Set for Healthcare Workers)

  • Measles (IgG EIA method)

  • Rubella (IgG EIA / HI method)

  • Mumps (IgG EIA method)

  • Varicella (IgG EIA method)

  • Hepatitis B (HBs Antibody CLIA method)

¥14,500
（¥15,950 tax included）

Individual tests ※1 ※2 can be added to the above sets.
Additional fee if required: Certificate issuance fee — Japanese: ¥3,500 (¥3,850 tax included) / English: ¥7,500 (¥8,250 tax included)

  • Individual Prices
Basic Antibody Virus
Test Set
Consultation fee, Procedure fee, and Evaluation fee
¥5,000
（¥5,500 tax included）
Measles Virus Antibody
IgG EIA method
¥2,200
（¥2,420 tax included）
Rubella Virus Antibody
IgG EIA / HI method
¥2,200
（¥2,420 tax included）
Mumps Virus Antibody
IgG EIA method
¥2,200
（¥2,420 tax included）
Varicella Virus Antibody
IgG EIA method
¥2,200
（¥2,420 tax included）
Hepatitis B Virus Antibody
IgG EIA / HI method
¥1,200
（¥1,320 tax included）
Hepatitis B Virus Antigen
(※1)
IgG EIA / HI method
¥1,200
（¥1,320 tax included）
Hepatitis C Virus Antibody
(※2)
IgG EIA / HI method
¥1,200
（¥1,320 tax included）

Additional fee if required: Certificate issuance fee — Japanese: ¥3,500 (¥3,850 tax included) / English: ¥7,500 (¥8,250 tax included)

  • Processing Time

5–7 days (Results will be explained and handed over during your visit to the clinic)

  • Criteria for Determining Antibody Positivity

Standard antibody titer values for the five major viruses

Disease / Virus
Test Method
Unit
Negative
(No detectable antibodies)
Insufficient Immunity
(Antibodies detected but below standard)
Positive
(Sufficient antibodies present)
Measles
EIA-IgGEIA Value< 2.02.0-15.9≥ 16.0
PA MethodTiter< 16x16x、32x、64x、128x≥ 256x
NTMethodTiter< 4x4x≥ 8x
Rubella
HI MethodTiter< 8x8x、16x≥ 32x
EIA-IgGEIA Value< 2.02.0-7.9≥ 8.0
Varicella
EIA-IgGEIA Value< 2.02.0-3.9≥ 4.0
IAHA MethodTiter< 2x2x≥ 4x
NT MethodTiter< 2x2x≥ 4x
Mumps
EIA-IgGEIA Value< 2.02.0-3.9≥ 4.0
Hepatitis B
(HBs Antibody)
CLIA MethodmIU/mI< 10.0ー≥ 10.0

Reference: Ministry of Health, Labour and Welfare website, Japanese Society for Environmental Infections Guidelines

  • What are Antibodies?

Antibodies are proteins called immunoglobulins.
When foreign substances (antigens※1) enter the body, antibodies※2 specifically bind to them and work to eliminate these foreign substances.

※1 Antigen: A foreign substance such as bacteria or viruses
※2 Antibody: A substance that attacks the antigen

When an antigen enters the body, it is called an infection. During the first infection, antibodies are produced slowly (primary response). However, from the second infection onward, a large number of antibodies are rapidly produced (secondary response).

  • Functions of Antibodies

Four Roles:

  • Neutralization of antigens
  • Opsonization
  • Cell lysis
  • Induction of inflammation
  • Types of Antibodies

Five Types

  • IgG: Found abundantly in the blood. It has a strong ability to bind to bacteria and viruses and remains in the bloodstream for a long time.
  • IgM: Produced quickly by B cells when encountering a specific antigen for the first time. It acts during the early stages of infection.
  • IgA: Found in higher amounts in intestinal secretions and body fluids. Plays an important role in preventing bacteria and viruses from invading through mucous membranes such as the nose and eyes.
  • IgD: Released from antibody-producing cells in the tonsils and respiratory tract. Believed to contribute to immunity in the respiratory system.
  • IgE: Binds to mast cells and triggers allergic reactions.
  • Antigen-Antibody Reaction

When the body is infected by a pathogen, it produces antibodies that specifically bind to that pathogen (antigen) and neutralize it, helping to defend the body.

The process by which antigens induce antibody production, and antibodies then react with the antigen, is called the antigen-antibody reaction.
If this reaction occurs excessively, it may cause allergic responses.
Vaccination is a preventive measure that utilizes the body’s ability to produce antibodies to protect against infection and disease.